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NDB ID: 6Z8V    PDB ID: 6Z8V 


Title:

X-RAY STRUCTURE OF THE COMPLEX BETWEEN HUMAN ALPHA THROMBIN AND A THROMBIN BINDING APTAMER VARIANT (TBA-3L), WHICH CONTAINS 1-BETA-D-LACTOPYRANOSYL RESIDUE IN THE SIDE CHAIN OF THY3 AT N3.

Molecular Description:

Prothrombin/DNA Complex

Deposited:

2020-06-02

Released:

2021-01-27

Structural Keywords:

QUADRUPLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Smirnov, I., Kolganova, N., Troisi, R., Sica, F., Timofeev, E.
Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12. 
Mol Ther Nucleic Acids, 23, pp. 863 - 871, 2021.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 32 2 1

Cell Constants:

a = 94.916   b = 94.916   c = 125.397 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.181 for 51616 reflections in the resolution range 82.2 to 1.58 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)