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NDB ID: 7ADV    PDB ID: 7ADV 


Title:

CRYSTAL STRUCTURE OF THE PROTOTYPE FOAMY VIRUS (PFV) INTASOME IN COMPLEX WITH MAGNESIUM AND THE INSTI XZ447 (COMPOUND 6V)

Molecular Description:

Integrase/DNA Complex

Deposited:

2020-09-16

Released:

2021-03-24

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Smith, S.J., Zhao, X.Z., Passos, D.O., Pye, V.E., Cherepanov, P., Lyumkis, D., Burke Jr., T.R., Hughes, S.H.
HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants. 
Acs Infect Dis., , pp. - , 2021.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 41 21 2

Cell Constants:

a = 158.61   b = 158.61   c = 122.95 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1971 for 45869 reflections in the resolution range 50.16 to 2.65 Ångstroms with Fobs >  1.36 sigma(Fobs) and with I >  0.0 sigma(I)