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NDB ID: 7AHX    PDB ID: 7AHX 


Title:

HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND D-ASPARTATE TENOFOVIR WITH BOUND MANGANESE

Molecular Description:

Gag-Pol polyprotein/DNA Complex

Deposited:

2020-09-25

Released:

2021-01-13

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Gu, W., Martinez, S., Nguyen, H., Xu, H., Herdewijn, P., De Jonghe, S., Das, K.
Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates-Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues. 
J.Med.Chem., , pp. - , 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 89.416   b = 132.371   c = 138.744 (Ångstroms)

α = 90.0   β = 98.48   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2153 for 84547 reflections in the resolution range 69.8 to 2.73 Ångstroms with Fobs >  1.46 sigma(Fobs) and with I >  0.0 sigma(I)