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NDB ID: 7AIF    PDB ID: 7AIF 


Title:

HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND L-GLUTAMATE TENOFOVIR WITH BOUND MANGANESE

Molecular Description:

Gag-Pol polyprotein/DNA Complex

Deposited:

2020-09-27

Released:

2021-01-13

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Gu, W., Martinez, S., Nguyen, H., Xu, H., Herdewijn, P., De Jonghe, S., Das, K.
Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates-Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues. 
J.Med.Chem., , pp. - , 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 89.651   b = 132.702   c = 138.77 (Ångstroms)

α = 90.0   β = 98.65   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2194 for 82034 reflections in the resolution range 80.14 to 2.75 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)