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NDB ID: 7AUD    PDB ID: 7AUD 


Title:

STRUCTURE OF AN ENGINEERED HELICASE DOMAIN CONSTRUCT FOR HUMAN BLOOM SYNDROME PROTEIN (BLM)

Molecular Description:

Bloom syndrome protein/DNA Complex

Deposited:

2020-11-02

Released:

2020-12-16

Structural Keywords:

SMALL NA FRAGMENT

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Chen, X., Ali, Y., Fisher, C.E.L., Arribas-Bosacoma, R., Rajasekaran, M.B., Williams, G., Walker, S., Roe, S.M., Pearl, L.H., Ward, S.E., Pearl, F.M.G., Oliver, A.W.
Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
Biorxiv, , pp. - , 2020.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1

Cell Constants:

a = 84.916   b = 111.709   c = 132.344 (Ångstroms)

α = 72.64   β = 80.18   γ = 79.22 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2311 for 91661 reflections in the resolution range 47.28 to 2.96 Ångstroms with Fobs >  1.97 sigma(Fobs) and with I >  0.0 sigma(I)