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NDB ID: 7KFN    PDB ID: 7KFN 


Title:

STRUCTURE OF HUMAN ADENOSINE DEAMINASE ACTING ON DSRNA (ADAR2) BOUND TO DSRNA CONTAINING A 2'-DEOXY BENNER'S BASE Z OPPOSITE THE EDITED BASE

Molecular Description:

Double-stranded RNA-specific editase 1/RNA Complex

Deposited:

2020-10-14

Released:

2021-06-16

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Doherty, E.E., Wilcox, X.E., van Sint Fiet, L., Kemmel, C., Turunen, J.J., Klein, B., Tantillo, D.J., Fisher, A.J., Beal, P.A.
Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position. 
J.Am.Chem.Soc., 143, pp. 6865 - 6876, 2021.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 172.024   b = 63.612   c = 132.149 (Ångstroms)

α = 90.0   β = 126.77   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.1733 for 37774 reflections in the resolution range 68.99 to 2.5 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)