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NDB ID: 7L35    PDB ID: 7L35 


Title:

HUMAN DNA LIGASE 1 - R771W NICKED DNA COMPLEX

Molecular Description:

DNA ligase 1/DNA Complex

Deposited:

2020-12-17

Released:

2021-01-13

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Jurkiw, T.J., Tumbale, P.P., Schellenberg, M.J., Cunningham-Rundles, C., Williams, R.S., O'Brien, P.J.
LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency
To be published, , pp. - , 0.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 71.33   b = 100.523   c = 116.088 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1643 for 57036 reflections in the resolution range 38.732 to 2.0 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)