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NDB ID: 7LH9    PDB ID: 7LH9 


Title:

CRYSTAL STRUCTURE OF BRPF2 PWWP DOMAIN IN COMPLEX WITH DNA

Molecular Description:

Bromodomain-containing protein 1/DNA Complex

Deposited:

2021-01-21

Released:

2021-02-17

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Zhang, M., Lei, M., Qin, S., Dong, A., Yang, A., Li, Y., Loppnau, P., Hughes, T.R., Min, J., Liu, Y.
Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains. 
Biochim Biophys Acta Gene Regul Mech, 1864, pp. 194688 - 194688, 2021.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 40.41   b = 216.113   c = 54.037 (Ångstroms)

α = 90.0   β = 109.42   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.227 for 24880 reflections in the resolution range 41.64 to 2.6 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)