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NDB ID: 7LPJ    PDB ID: 7LPJ 


Title:

APE1 MN-BOUND PHOSPHOROTHIOATE SUBSTRATE COMPLEX WITH ABASIC RIBONUCLEOTIDE DNA

Molecular Description:

Deposited:

2021-02-11

Released:

2021-08-04

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Hoitsma, N.M., Click, T.H., Agarwal, P.K., Freudenthal, B.D.
Altered APE1 activity on abasic ribonucleotides is mediated by changes in the nucleoside sugar pucker. 
Comput Struct Biotechnol J, 19, pp. 3293 - 3302, 2021.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1

Cell Constants:

a = 44.171   b = 60.901   c = 73.32 (Ångstroms)

α = 82.913   β = 77.583   γ = 86.245 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1888 for 31441 reflections in the resolution range 48.82 to 2.56 Ångstroms with Fobs >  1.97 sigma(Fobs) and with I >  0.0 sigma(I)