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NDB ID: 7NBL    PDB ID: 7NBL 


Title:

SOLUTION STRUCTURE OF DNA:RNA HYBRID CONTAINING A 2'-DEOXY-2'2'-DIFLUORODEOXYCYTIDINE (GEMCITABINE) MODIFICATION

Molecular Description:

DNA (5'-D(*CP*TP*AP*(FFC)P*AP*CP*GP*G)-3')
RNA (5'-R(*CP*CP*GP*UP*GP*UP*AP*G)-3')

Deposited:

2021-01-27

Released:

2021-04-07

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Cabrero, C., Martin-Pintado, N., Mazzini, S., Gargallo, R., Eritja, R., Avino, A., Gonzalez, C.
Structural Effects of Incorporation of 2 -Deoxy-2 2 -difluorodeoxycytidine (Gemcitabine) in A- and B-form Duplexes. 
Chemistry, , pp. - , 2021.

Experimental Information:

SOLUTION NMR

Number of Models:

Number of Models: 10 Structures

Sample Details:

0.5 M DNA (5'-D(*CP*TP*AP*(FFC)P*AP*CP*GP*G)-3'), 0.5 M RNA (5'-R(*CP*CP*GP*UP*GP*UP*AP*G)-3'), 25 mM sodium phosphate, 100 mM sodium chloride, 0.5 % v/v DSS, 90% H2O/10% D2O 90% H2O/10% D2O