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NDB ID: 7RQ9    PDB ID: 7RQ9 


Title:

CRYSTAL STRUCTURE OF THE A2058-DIMETHYLATED THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH IBOXAMYCIN, MRNA, DEACYLATED A- AND E-SITE TRNAS, AND AMINOACYLATED P-SITE TRNA AT 2.60A RESOLUTION

Molecular Description:

Deposited:

2021-08-06

Released:

2021-10-13

Nucleic Acid Sequence:

Click to show/hide 7 nucleic acid sequences

Protein Sequence:

Click to show/hide 49 protein sequences

Primary Citation:

Mitcheltree, M.J., Pisipati, A., Syroegin, E.A., Silvestre, K.J., Klepacki, D., Mason, J.D., Terwilliger, D.W., Testolin, G., Pote, A.R., Wu, K.J.Y., Ladley, R.P., Chatman, K., Mankin, A.S., Polikanov, Y.S., Myers, A.G.
A synthetic antibiotic scaffold effective against multidrug-resistant bacterial pathogens
To Be Published, , pp. - , 0.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 208.8   b = 444.65   c = 619.33 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2438 for 1706669 reflections in the resolution range 106.53 to 2.6 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)