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NDB ID: AD0028    PDB ID: 1MLX 


Title:

CRYSTAL STRUCTURE ANALYSIS OF A 2'-O-[2-(METHYLTHIO)-ETHYL]-MODIFIED OLIGODEOXYNUCLEOTIDE DUPLEX

Molecular Description:

5'-D(*GP*CP*GP*TP*AP*SMTP*AP*CP*GP*C)-3'

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Prakash, T.P., Manoharan, M., Kawasaki, A.M., Fraser, A.S., Lesnik, E.A., Sioufi, N., Leeds, J.M., Teplova, M., Egli, M.
2'-O-[2-(Methylthio)ethyl]-Modified Oligonucleotide: An Analogue of 2'-O-[2-(Methoxy)-ethyl]-Modified Oligonucleotide with Improved Protein Binding Properties and High Binding Affinity to Target RNA 
Biochemistry, 41, pp. 11642 - 11648, 2002.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 24.728   b = 44.473   c = 46.229 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the SHELXL-97 program. The R value is 0.137 for 12784 reflections in the resolution range 15.0 to 1.25 Ångstroms with Fobs >  4.0 sigma(Fobs) and with I >  2.0 sigma(I)