A Portal for Three-dimensional Structural Information about Nucleic Acids
As of 17-Aug-2016 number of released structures: 8433
Search for released structures

NDB ID: AD0061    PDB ID: 2FIL 


Title:

CRYSTAL STRUCTURE ANALYSIS OF THE A-DNA DECAMER GCGT-2'OMEA-FAT-ACGC, WITH INCORPORATED 2'-O-METHYLATED-ADENOSINE (2'OMEA) AND 2'-FLUOROARABINO-THYMIDINE (FAT)

Molecular Description:

5'-D(*GP*CP*GP*TP*(A2M)P*(TAF)P*AP*CP*GP*C)-3'

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Li, F., Sarkhel, S., Wilds, C.J., Wawrzak, Z., Prakash, T.P., Manoharan, M., Egli, M.
2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H. 
Biochemistry, 45, pp. 4141 - 4152, 2006.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 32.733   b = 69.18   c = 32.831 (Ångstroms)

α = 90.0   β = 92.21   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC 5.2.0003 program. The R value is 0.20401 for 15695 reflections in the resolution range 30.0 to 1.69 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)