CRYSTAL STRUCTURE ANALYSIS OF THE A-DNA DECAMER GCGT-2'OMEA-FAT-ACGC, WITH INCORPORATED 2'-O-METHYLATED-ADENOSINE (2'OMEA) AND 2'-FLUOROARABINO-THYMIDINE (FAT)
A DOUBLE HELIX
Chain A, B, C, D
No Protein Sequence Found
Li, F., Sarkhel, S., Wilds, C.J., Wawrzak, Z., Prakash, T.P., Manoharan, M., Egli, M.
2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H.
Biochemistry, 45, pp. 4141 - 4152, 2006.
P 1 21 1
a = 32.733 b = 69.18 c = 32.831 (Ångstroms)
α = 90.0 β = 92.21 γ = 90.0 (degrees)
The structure was refined using the REFMAC 5.2.0003 program. The R value is 0.20401 for 15695 reflections in the resolution range 30.0 to 1.69 Ångstroms with Fobs > 0.0 sigma(Fobs) and with I > 0.0 sigma(I)