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NDB ID: AHH0114    PDB ID: 398D 


Title:

3'-DNA-RNA-5' JUNCTION FORMED DURING INITIATION OF MINUS-STRAND SYNTHESIS OF HIV REPLICATION

Molecular Description:

5'-R(*GP*CP*AP*GP*UP*GP*GP*C)-3'
5'-R(*GP*CP*CP*AP)-D(*CP*TP*GP*C)-3'

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Mueller, U., Maier, G., Mochi Onori, A., Cellai, L., Heumann, H., Heinemann, U.
Crystal structure of an eight-base pair duplex containing the 3'-DNA-RNA-5' junction formed during initiation of minus-strand synthesis of HIV replication. 
Biochemistry, 37, pp. 12005 - 12011, 1998.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 42.74   b = 44.15   c = 51.93 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the X-PLOR program. The R value is 0.22 for 7566 reflections in the resolution range 15.0 to 1.94 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)