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NDB ID: AR0016    PDB ID: 468D 


Title:

CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA

Molecular Description:

5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3'

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Teplova, M., Minasov, G., Tereshko, V., Inamati, G.B., Cook, P.D., Manoharan, M., Egli, M.
Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA. 
Nat.Struct.Biol., 6, pp. 535 - 539, 1999.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 41.32   b = 34.55   c = 46.6 (Ångstroms)

α = 90.0   β = 92.3   γ = 90.0 (degrees)

Refinement:

The structure was refined using the X-PLOR 3.851 program. The R value is 0.207 for 5532 reflections in the resolution range 8.0 to 1.8 Ångstroms with Fobs >  2.0 sigma(Fobs) and with I >  0.0 sigma(I)