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NDB ID: AR0068    PDB ID: 2G92 


Title:

CRYSTAL STRUCTURE ANALYSIS OF THE RNA DODECAMER CGC-(NF2)-AAUUAGCG, WITH AN INCORPORATED 2,4-DIFLUOROTOLUYL RESIDUE (NF2)

Molecular Description:

5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*AP*GP*CP*G)-3'

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Xia, J., Noronha, A., Toudjarska, I., Li, F., Akinc, A., Braich, R., Frank-Kamenetsky, M., Rajeev, K.G., Egli, M., Manoharan, M.
Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide. 
Acs Chem.Biol., 1, pp. 176 - 183, 2006.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 31

Cell Constants:

a = 28.614   b = 28.614   c = 63.171 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC 5.2.0003 program. The R value is 0.199 for 7425 reflections in the resolution range 24.78 to 1.61 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)