CRYSTAL STRUCTURE ANALYSIS OF THE RNA DODECAMER CGC-NF2-AAUUGGCG, WITH AN INCORPORATED 2,4-DIFLUOROTOLUYL RESIDUE (NF2)
A DOUBLE HELIX
Chain A, B, C, D
No Protein Sequence Found
Li, F., Pallan, P.S., Maier, M.A., Rajeev, K.G., Mathieu, S.L., Kreutz, C., Fan, Y., Sanghvi, J., Micura, R., Rozners, E., Manoharan, M., Egli, M.
Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Nucleic Acids Res., 35, pp. 6424 - 6438, 2007.
a = 22.9 b = 32.06 c = 42.93 (Ångstroms)
α = 96.24 β = 83.87 γ = 93.91 (degrees)
The structure was refined using the SHELXL-97 program. The R value is 0.11 for 43113 reflections in the resolution range 10.0 to 1.1 Ångstroms with Fobs > 4.0 sigma(Fobs) and with I > 0.0 sigma(I)