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NDB ID: AR0080    PDB ID: 2Q1O 


Title:

CRYSTAL STRUCTURE ANALYSIS OF THE RNA DODECAMER CGC-NF2-AAUUGGCG, WITH AN INCORPORATED 2,4-DIFLUOROTOLUYL RESIDUE (NF2)

Molecular Description:

5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*GP*GP*CP*G)-3'

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Li, F., Pallan, P.S., Maier, M.A., Rajeev, K.G., Mathieu, S.L., Kreutz, C., Fan, Y., Sanghvi, J., Micura, R., Rozners, E., Manoharan, M., Egli, M.
Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme. 
Nucleic Acids Res., 35, pp. 6424 - 6438, 2007.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1

Cell Constants:

a = 22.9   b = 32.06   c = 42.93 (Ångstroms)

α = 96.24   β = 83.87   γ = 93.91 (degrees)

Refinement:

The structure was refined using the SHELXL-97 program. The R value is 0.11 for 43113 reflections in the resolution range 10.0 to 1.1 Ångstroms with Fobs >  4.0 sigma(Fobs) and with I >  0.0 sigma(I)