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NDB ID: DDH048    PDB ID: 173D 


Title:

MULTIPLE BINDING MODES OF ANTICANCER DRUG ACTINOMYCIN D: X-RAY, MOLECULAR MODELING, AND SPECTROSCOPIC STUDIES OF D(GAAGCTTC)2-ACTINOMYCIN D COMPLEXES AND ITS HOST DNA

Molecular Description:

ACTINOMYCIN D/DNA Complex

Deposited:

1994-04-18

Released:

1994-10-15

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Kamitori, S., Takusagawa, F.
Multiple Binding Modes of Anticancer Drug Actinomycin D: X-Ray, Molecular Modeling, and Spectroscopic Studies of D(Gaagcttc)2-Actinomycin D Complexes and its Host DNA
J.Am.Chem.Soc., 116, pp. 4154 - , 1994.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

F 2 2 2

Cell Constants:

a = 69.9   b = 61.41   c = 54.25 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the X-PLOR program. The R value is 0.202 for 1016 reflections in the resolution range 8.0 to 3.0 Ångstroms with Fobs >  2.0 sigma(Fobs) and with I >  0.0 sigma(I)