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NDB ID: DDH071    PDB ID: 316D 


Title:

SELECTIVITY OF F8-ACTINOMYCIN D FOR RNA:DNA HYBRIDS AND ITS ANTI-LEUKEMIA ACTIVITY

Molecular Description:

8-FLUORO-ACTINOMYCIN D/DNA Complex

Deposited:

1997-03-05

Released:

1997-11-05

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Takusagawa, F., Takusagawa, K.T., Carlson, R.G., Weaver, R.F.
Selectivity of F8-Actinomycin D for RNA:DNA Hybrids and its Anti-Leukemia Activity. 
Bioorg.Med.Chem., 5, pp. 1197 - , 1997.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 31 2 1

Cell Constants:

a = 62.77   b = 62.77   c = 43.03 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the X-PLOR program. The R value is 0.212 for 1839 reflections in the resolution range 7.0 to 3.0 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)