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NDB ID: DR0036    PDB ID: 2OE8 


Title:

1.8 A X-RAY CRYSTAL STRUCTURE OF APRAMYCIN COMPLEX WITH RNA FRAGMENT GGGCGUCGCUAGUACC/CGGUACUAAAAGUCGCC CONTAINING THE HUMAN RIBOSOMAL DECODING A SITE: RNA CONSTRUCT WITH 5'-OVERHANG

Molecular Description:

Synthetic RNA fragment containing the human ribosomal decoding A site
apramycin

Structural Keywords:

A DOUBLE HELIX, OVERHANGING BASES, MISMATCHED BASE PAIR, BULGE

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Hermann, T., Tereshko, V., Skripkin, E., Patel, D.J.
Apramycin recognition by the human ribosomal decoding site. 
Blood Cells Mol.Dis., 38, pp. 193 - 198, 2007.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 27.858   b = 37.259   c = 85.586 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC 5 program. The R value is 0.20984 for 8264 reflections in the resolution range 20.0 to 1.8 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)