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NDB ID: DR0037    PDB ID: 2O3V 


Title:

CRYSTAL STRUCTURE OF THE HOMO SAPIENS CYTOPLASMIC RIBOSOMAL DECODING SITE COMPLEXED WITH PAROMAMINE DERIVATIVE NB33

Molecular Description:

5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3'
Paromamine derivative

Structural Keywords:

A DOUBLE HELIX, MISMATCHED BASE PAIR, INTERNAL LOOP, OVERHANGING BASE

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Kondo, J., Hainrichson, M., Nudelman, I., Shallom-Shezifi, D., Barbieri, C.M., Pilch, D.S., Westhof, E., Baasov, T.
Differential Selectivity of Natural and Synthetic Aminoglycosides towards the Eukaryotic and Prokaryotic Decoding A Sites. 
Chembiochem, 8, pp. 1700 - 1709, 2007.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 28.62   b = 41.22   c = 56.91 (Ångstroms)

α = 90.0   β = 104.32   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 2995 reflections in the resolution range 27.73 to 2.8 Ångstroms with Fobs >  3.0 sigma(Fobs) and with I >  0.0 sigma(I)