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NDB ID: DR0038    PDB ID: 2O3W 


Title:

CRYSTAL STRUCTURE OF THE HOMO SAPIENS CYTOPLASMIC RIBOSOMAL DECODING SITE IN PRESENCE OF PAROMOMYCIN

Molecular Description:

5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3'
Paromomycin

Structural Keywords:

A DOUBLE HELIX, MISMATCHED BASE PAIR, INTERNAL LOOP

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Kondo, J., Hainrichson, M., Nudelman, I., Shallom-Shezifi, D., Barbieri, C.M., Pilch, D.S., Westhof, E., Baasov, T.
Differential Selectivity of Natural and Synthetic Aminoglycosides towards the Eukaryotic and Prokaryotic Decoding A Sites. 
Chembiochem, 8, pp. 1700 - 1709, 2007.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 47.537   b = 50.31   c = 57.397 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 3480 reflections in the resolution range 57.35 to 2.8 Ångstroms with Fobs >  3.0 sigma(Fobs) and with I >  0.0 sigma(I)