A Portal for Three-dimensional Structural Information about Nucleic Acids
As of 21-Sep-2016 number of released structures: 8505
Search for released structures

NDB ID: DR0040    PDB ID: 2PWT 


Title:

CRYSTAL STRUCTURE OF THE BACTERIAL RIBOSOMAL DECODING SITE COMPLEXED WITH AMINOGLYCOSIDE CONTAINING THE L-HABA GROUP

Molecular Description:

22-mer of the ribosomal decoding site/paromomycin derivative

Structural Keywords:

RH DOUBLE HELIX, LOOPS, HAIRPIN LOOP, FLIPPED-OUT BASES, BULGES

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Kondo, J., Pachamuthu, K., Francois, B., Szychowski, J., Hanessian, S., Westhof, E.
Crystal Structure of the Bacterial Ribosomal Decoding Site Complexed with a Synthetic Doubly Functionalized Paromomycin Derivative: a New Specific Binding Mode to an A-Minor Motif Enhances in vitro Antibacterial Activity 
Chemmedchem, 2, pp. 1631 - 1638, 2007.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 35.49   b = 43.02   c = 98.75 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 14603 reflections in the resolution range 32.0 to 1.8 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)