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NDB ID: DR0042    PDB ID: 3C44 


Title:

CRYSTAL STRUCTURE OF HIV-1 SUBTYPE F DIS EXTENDED DUPLEX RNA BOUND TO PAROMOMYCIN

Molecular Description:

HIV-1 subtype F genomic RNA
PAROMOMYCIN

Structural Keywords:

A DOUBLE HELIX, BULGES, FLIPPED-OUT BASES

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Freisz, S., Lang, K., Micura, R., Dumas, P., Ennifar, E.
Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA dimerization initiation site. 
Angew.Chem.Int.Ed.Engl., 47, pp. 4110 - 4113, 2008.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 30.818   b = 95.703   c = 47.856 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS 1.1 program. The R value is 0.224 for 9315 reflections in the resolution range 26.55 to 2.0 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)