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NDB ID: GDL022    PDB ID: 127D     NAKB(beta): GDL022 


Title:

DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3') COMPLEXED WITH HOECHST 33258

Molecular Description:

5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'
HOECHST 33258

Deposited:

1993-06-30

Released:

1994-01-15

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Sriram, M., van der Marel, G.A., Roelen, H.L., van Boom, J.H., Wang, A.H.
Conformation of B-DNA containing O6-ethyl-G-C base pairs stabilized by minor groove binding drugs: molecular structure of d(CGC[e6G]AATTCGCG complexed with Hoechst 33258 or Hoechst 33342. 
EMBO J., 11, pp. 225 - 232, 1992.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 25.23   b = 40.58   c = 66.08 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the NUCLSQ program. The R value is 0.172 for 2000 reflections in the resolution range 0.0 to 2.0 Ångstroms with Fobs >  2.0 sigma(Fobs) and with I >  0.0 sigma(I)