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NDB ID: GDLB20    PDB ID: 130D 


Title:

MOLECULAR STRUCTURE OF D(CGC[E6G]AATTCGCG) COMPLEXED WITH HOECHST 33342

Molecular Description:

5'-D(*CP*GP*CP*(G36)P*AP*AP*TP*TP*CP*GP*CP*G)-3'
HOECHST 33342

Deposited:

1993-06-30

Released:

1994-01-15

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Sriram, M., van der Marel, G.A., Roelen, H.L., van Boom, J.H., Wang, A.H.
Conformation of B-DNA containing O6-ethyl-G-C base pairs stabilized by minor groove binding drugs: molecular structure of d(CGC[e6G]AATTCGCG complexed with Hoechst 33258 or Hoechst 33342. 
EMBO J., 11, pp. 225 - 232, 1992.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 25.71   b = 41.32   c = 67.08 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the NUCLSQ program. The R value is 0.157 for 1194 reflections in the resolution range 0.0 to 2.5 Ångstroms with Fobs >  2.0 sigma(Fobs) and with I >  0.0 sigma(I)