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NDB ID: NA0064    PDB ID: 3HXQ 


Title:

CRYSTAL STRUCTURE OF VON WILLEBRAND FACTOR (VWF) A1 DOMAIN IN COMPLEX WITH DNA APTAMER ARC1172, AN INHIBITOR OF VWF-PLATELET BINDING

Molecular Description:

von Willebrand Factor/DNA complex

Deposited:

2009-06-21

Released:

2009-11-17

Structural Keywords:

, HAIRPIN LOOP

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Huang, R.H., Fremont, D.H., Diener, J.L., Schaub, R.G., Sadler, J.E.
A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1. 
Structure, 17, pp. 1476 - 1484, 2009.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 117.781   b = 48.512   c = 62.16 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.223 for 9783 reflections in the resolution range 38.0 to 2.694 Ångstroms with Fobs >  1.5 sigma(Fobs) and with I >  0.0 sigma(I)