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NDB ID: NA0071    PDB ID: 3HXM 


Title:

STRUCTURE OF AN ARGONAUTE COMPLEXED WITH GUIDE DNA AND TARGET RNA DUPLEX CONTAINING TWO MISMATCHES.

Molecular Description:

Argonaute/DNA/RNA complex

Structural Keywords:

A DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Wang, Y., Juranek, S., Li, H., Sheng, G., Wardle, G.S., Tuschl, T., Patel, D.J.
Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. 
Nature, 461, pp. 754 - 761, 2009.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 121.839   b = 118.867   c = 59.186 (Ångstroms)

α = 90.0   β = 114.79   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 13142 reflections in the resolution range 30.0 to 3.1 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)