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NDB ID: NA0072    PDB ID: 3HVR 


Title:

CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE COMPLEXED WITH DNA GUIDE STRAND AND 19-NT RNA TARGET STRAND WITH TWO MG2+ AT THE CLEAVAGE SITE

Molecular Description:

argonaute/DNA/RNA complex

Structural Keywords:

A DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Wang, Y., Juranek, S., Li, H., Sheng, G., Wardle, G.S., Tuschl, T., Patel, D.J.
Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. 
Nature, 461, pp. 754 - 761, 2009.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 111.252   b = 116.903   c = 170.504 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX (phenix.refine) program. The R value is 0.229 for 34940 reflections in the resolution range 37.68 to 3.211 Ångstroms with Fobs >  0.13 sigma(Fobs) and with I >  0.0 sigma(I)