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NDB ID: NA0250    PDB ID: 2W7P 


Title:

STRUCTURE AND ACTIVITY OF BYPASS SYNTHESIS BY HUMAN DNA POLYMERASE KAPPA OPPOSITE THE 7,8-DIHYDRO-8-OXODEOXYGUANOSINE ADDUCT

Molecular Description:

DNA POLYMERASE KAPPA (E.C.2.7.7.7)

Deposited:

2008-12-23

Released:

2009-06-16

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Irimia, A., Eoff, R.L., Guengerich, F.P., Egli, M.
Structural and Functional Elucidation of the Mechanism Promoting Error-Prone Synthesis by Human DNA Polymerase Kappa Opposite the 7,8-Dihydro-8-Oxo-2'-Deoxyguanosine Adduct. 
J.Biol.Chem., 284, pp. 22467 - , 2009.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 167.829   b = 220.847   c = 119.208 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.236 for 23026 reflections in the resolution range 44.65 to 3.71 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)