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NDB ID: NA0325    PDB ID: 3KLF 


Title:

CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO A DSDNA WITH A BOUND EXCISION PRODUCT, AZTPPPPA

Molecular Description:

Deposited:

2009-11-07

Released:

2010-09-22

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Tu, X., Das, K., Han, Q., Bauman, J.D., Clark, A.D., Hou, X., Frenkel, Y.V., Gaffney, B.L., Jones, R.A., Boyer, P.L., Hughes, S.H., Sarafianos, S.G., Arnold, E.
Structural basis of HIV-1 resistance to AZT by excision. 
Nat.Struct.Mol.Biol., 17, pp. 1202 - 1209, 2010.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 78.529   b = 274.806   c = 152.371 (Ångstroms)

α = 90.0   β = 90.11   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.264 for 98356 reflections in the resolution range 24.83 to 3.15 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)