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NDB ID: NA0411    PDB ID: 3L25 


Title:

CRYSTAL STRUCTURE OF ZAIRE EBOLA VP35 INTERFERON INHIBITORY DOMAIN BOUND TO 8 BP DSRNA

Molecular Description:

Polymerase cofactor VP35

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Leung, D.W., Prins, K.C., Borek, D.M., Farahbakhsh, M., Tufariello, J.M., Ramanan, P., Nix, J.C., Helgeson, L.A., Otwinowski, Z., Honzatko, R.B., Basler, C.F., Amarasinghe, G.K.
Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35. 
Nat.Struct.Mol.Biol., 17, pp. 165 - 172, 2010.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 78.947   b = 84.571   c = 89.316 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC 5.3.0037 program. The R value is 0.17129 for 39012 reflections in the resolution range 44.68 to 2.0 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)