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NDB ID: NA0434    PDB ID: 3LK9 


Title:

DNA POLYMERASE BETA WITH A GAPPED DNA SUBSTRATE AND DTMP(CF2)P(CF2)P

Molecular Description:

DNA polymerase beta (E.C.2.7.7.7
4.2.99.-)

Deposited:

2010-01-27

Released:

2011-01-12

Structural Keywords:

B DOUBLE HELIX, NICKED

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Surya Prakash, G.K., Zibinsky, M., Upton, T.G., Kashemirov, B.A., McKenna, C.E., Oertell, K., Goodman, M.F., Batra, V.K., Pedersen, L.C., Beard, W.A., Shock, D.D., Wilson, S.H., Olah, G.A.
Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. 
Proc.Natl.Acad.Sci.USA, 107, pp. 15693 - 15698, 2010.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 49.96   b = 79.8   c = 55.05 (Ångstroms)

α = 90.0   β = 108.46   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.198 for 13016 reflections in the resolution range 24.28 to 2.5 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)