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NDB ID: NA0449    PDB ID: 3L8B 


Title:

CRYSTAL STRUCTURE OF A REPLICATIVE DNA POLYMERASE BOUND TO THE OXIDIZED GUANINE LESION GUANIDINOHYDANTOIN

Molecular Description:

DNA polymerase (E.C.2.7.7.7)/DNA Complex

Deposited:

2009-12-30

Released:

2010-03-09

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Aller, P., Ye, Y., Wallace, S.S., Burrows, C.J., Doublie, S.
Crystal structure of a replicative DNA polymerase bound to the oxidized guanine lesion guanidinohydantoin. 
Biochemistry, 49, pp. 2502 - 2509, 2010.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 78.276   b = 120.246   c = 136.963 (Ångstroms)

α = 90.0   β = 95.96   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 239932 reflections in the resolution range 48.81 to 2.15 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)