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NDB ID: NA0478    PDB ID: 3M4O 


Title:

RNA POLYMERASE II ELONGATION COMPLEX B

Molecular Description:

DNA-directed RNA polymerase II subunit RPB1 (E.C.2.7.7.6)
DNA-directed RNA polymerase II subunit RPB2 (E.C.2.7.7.6)
DNA-directed RNA polymerase II subunit RPB3
DNA-directed RNA polymerases I
II
and III subunit RPABC1
DNA-directed RNA polymerases I
II
and III subunit RPABC2
DNA-directed RNA polymerases I
II
and III subunit RPABC3
DNA-directed RNA polymerase II subunit RPB9
DNA-directed RNA polymerases I
II
and III subunit RPABC5
DNA-directed RNA polymerase II subunit RPB11
DNA-directed RNA polymerases I
II
and III subunit RPABC4

Structural Keywords:

DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 10 protein sequences

Primary Citation:

Wang, D., Zhu, G., Huang, X., Lippard, S.J.
X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct. 
Proc.Natl.Acad.Sci.USA, 107, pp. 9584 - 9589, 2010.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 168.114   b = 222.131   c = 191.782 (Ångstroms)

α = 90.0   β = 100.99   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC 5.5.0102 program. The R value is 0.24391 for 70340 reflections in the resolution range 40.0 to 3.57 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)