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NDB ID: NA0494    PDB ID: 3MDC 


Title:

DNA POLYMERASE LAMBDA IN COMPLEX WITH DFDCTP

Molecular Description:

DNA polymerase lambda (E.C.2.7.7.7
4.2.99.-)

Deposited:

2010-03-30

Released:

2010-04-28

Structural Keywords:

B DOUBLE HELIX, NICKED

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Garcia-Diaz, M., Murray, M.S., Kunkel, T.A., Chou, K.M.
Interaction between DNA Polymerase lambda and anticancer nucleoside analogs. 
J.Biol.Chem., 285, pp. 16874 - 16879, 2010.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 55.206   b = 59.773   c = 142.008 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.219 for 29110 reflections in the resolution range 24.679 to 1.999 Ångstroms with Fobs >  0.02 sigma(Fobs) and with I >  0.0 sigma(I)