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NDB ID: NA0499    PDB ID: 3M9N 


Title:

CRYSTAL STRUCTURE OF DPO4 IN COMPLEX WITH DNA CONTAINING THE MAJOR CISPLATIN LESION

Molecular Description:

DNA polymerase IV (E.C.2.7.7.7)

Deposited:

2010-03-22

Released:

2010-06-16

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Wong, J.H., Brown, J.A., Suo, Z., Blum, P., Nohmi, T., Ling, H.
Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4. 
Embo J., 29, pp. 2059 - 2069, 2010.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 98.227   b = 103.233   c = 52.259 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.245 for 40274 reflections in the resolution range 27.6 to 1.93 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)