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NDB ID: NA0616    PDB ID: 3NBN 


Title:

CRYSTAL STRUCTURE OF A DIMER OF NOTCH TRANSCRIPTION COMPLEX TRIMERS ON HES1 DNA

Molecular Description:

Recombining binding protein suppressor of hairless
Neurogenic locus notch homolog protein 1
Mastermind-like protein 1/DNA Complex

Deposited:

2010-06-03

Released:

2010-11-03

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 3 protein sequences

Primary Citation:

Arnett, K.L., Hass, M., McArthur, D.G., Ilagan, M.X., Aster, J.C., Kopan, R., Blacklow, S.C.
Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. 
Nat.Struct.Mol.Biol., 17, pp. 1312 - 1317, 2010.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 295.112   b = 108.059   c = 87.239 (Ångstroms)

α = 90.0   β = 102.52   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.256 for 35361 reflections in the resolution range 45.02 to 3.45 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)