NDB ID: NA0645    PDB ID: 2XCS     NAKB(beta): NA0645 

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Title:

THE 2.1A CRYSTAL STRUCTURE OF S. AUREUS GYRASE COMPLEX WITH GSK299423 AND DNA

Molecular Description:

DNA GYRASE SUBUNIT B
DNA GYRASE SUBUNIT A (E.C.5.99.1.3)

Deposited:

2010-04-25

Released:

2010-08-04

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Bax, B.D., Chan, P.F., Eggleston, D.S., Fosberry, A., Gentry, D.R., Gorrec, F., Giordano, I., Hann, M.M., Hennessy, A., Hibbs, M., Huang, J., Jones, E., Jones, J., Brown, K.K., Lewis, C.J., May, E.W., Saunders, M.R., Singh, O., Spitzfaden, C., Shen, C., Shillings, A., Theobald, A.F., Wohlkonig, A., Pearson, N.D., Gwynn, M.N.
Type Iia Topoisomerase Inhibition by a New Class of Antibacterial Agents. 
Nature, 466, pp. 935 - , 2010.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 61

Cell Constants:

a = 93.318   b = 93.318   c = 412.812 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.18373 for 113168 reflections in the resolution range 20.0 to 2.1 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)

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Asymmetric Unit coordinates (pdb format, Unix compressed(.gz))

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Biological Assembly coordinates (pdb format) 1

Structure Factors (cif format)

Coordinates (pdb format, Unix compressed(.gz))

Coordinates (cif format, Unix compressed(.gz))

NMR Restraints (cif format, Unix compressed(.gz))

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