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NDB ID: NA0646    PDB ID: 3O62 


Title:

NUCLEOSOME CORE PARTICLE MODIFIED WITH A CISPLATIN 1,3-CIS-{PT(NH3)2}2+-D(GPTPG) INTRASTRAND CROSS-LINK

Molecular Description:

Histone H3.2
Histone H4
Histone H2A type 1
Histone H2B 1.1/DNA complex

Deposited:

2010-07-28

Released:

2011-01-05

Structural Keywords:

B DOUBLE HELIX, INTERNAL LOOP, FLIPPED-OUT BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 4 protein sequences

Primary Citation:

Todd, R.C., Lippard, S.J.
Consequences of Cisplatin binding on nucleosome structure and dynamics. 
Chem.Biol., 17, pp. 1334 - 1343, 2010.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 106.095   b = 109.551   c = 177.176 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.25216 for 22367 reflections in the resolution range 42.03 to 3.216 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)