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NDB ID: NA0655    PDB ID: 3OD8 


Title:

HUMAN PARP-1 ZINC FINGER 1 (ZN1) BOUND TO DNA

Molecular Description:

Poly [ADP-ribose] polymerase 1 (E.C.2.4.2.30)/DNA complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Langelier, M.F., Planck, J.L., Roy, S., Pascal, J.M.
Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY. 
J.Biol.Chem., 286, pp. 10690 - 10701, 2011.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 63.219   b = 107.696   c = 86.138 (Ångstroms)

α = 90.0   β = 100.2   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX (phenix.refine: 1.6.1_357) program. The R value is 0.1941 for 44511 reflections in the resolution range 42.609 to 2.4 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)