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NDB ID: NA0657    PDB ID: 3ODC 


Title:

HUMAN PARP-1 ZINC FINGER 2 (ZN2) BOUND TO DNA

Molecular Description:

Poly [ADP-ribose] polymerase 1(E.C.2.4.2.30)

Deposited:

2010-08-11

Released:

2011-01-12

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Langelier, M.F., Planck, J.L., Roy, S., Pascal, J.M.
Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY. 
J.Biol.Chem., 286, pp. 10690 - 10701, 2011.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 31 2 1

Cell Constants:

a = 63.731   b = 63.731   c = 192.405 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.195 for 11798 reflections in the resolution range 36.262 to 2.8 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)