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NDB ID: NA0742    PDB ID: 3OSN 


Title:

STRUCTURAL BASIS FOR PROFICIENT INCORPORATION OF DTTP OPPOSITE O6-METHYLGUANINE BY HUMAN DNA POLYMERASE IOTA

Molecular Description:

DNA Polymerase Iota (EC 2.7.7.7)/DNA Complex

Deposited:

2010-09-09

Released:

2010-10-20

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Pence, M.G., Choi, J.Y., Egli, M., Guengerich, F.P.
Structural Basis for Proficient Incorporation of dTTP Opposite O6-Methylguanine by Human DNA Polymerase {iota}. 
J.Biol.Chem., 285, pp. 40666 - 40672, 2010.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 65 2 2

Cell Constants:

a = 97.973   b = 97.973   c = 202.757 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.2098 for 43636 reflections in the resolution range 47.62 to 1.9 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)