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NDB ID: NA0798    PDB ID: 3OYN 


Title:

CRYSTAL STRUCTURE OF THE PFV N224H MUTANT INTASOME BOUND TO MAGNESIUM AND THE INSTI MK2048

Molecular Description:

PFV integrase

Deposited:

2010-09-23

Released:

2010-11-17

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Hare, S., Vos, A.M., Clayton, R.F., Thuring, J.W., Cummings, M.D., Cherepanov, P.
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. 
Proc.Natl.Acad.Sci.USA, 107, pp. 20057 - 20062, 2010.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 41 21 2

Cell Constants:

a = 160.67   b = 160.67   c = 123.05 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.2092 for 44428 reflections in the resolution range 38.97 to 2.68 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)