NDB ID: NA0851 PDB ID: 3PGW 
NAKB(beta): NA0851 
Title:
CRYSTAL STRUCTURE OF HUMAN U1 SNRNP
Molecular Description:
U1-A
U1-70K
Sm-D3
Sm B
Sm-D1
Sm-D2
Sm-F
Sm-E
Sm G
Deposited:
2010-11-02
Released:
2010-12-29
Nucleic Acid Sequence:
Click to show/hide 2 nucleic acid sequences
Chain D,M
(DA)(DG)(DG)(DT)(DA)(DA)(DG)(DT)(DA)
Chain R,N
AUACUUACCUGGCAGGGGAGAUACCAUGAUCACGAAGGUGGUUUUCCCAGGGCGAGGCUUAUCCAUUGCACUCCGGAUGU GCUGACCCC
UGCGAUUUCCCCAAAUGUGGGAAACUCGACUGCAUAAUUUGUGGUAGUGGGGGACUGCGUUCGCGCUUUCC CCUG
Protein Sequence:
Click to show/hide 9 protein sequences
Chain A,P
MAVPETRPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDILVSRSLKMRGQAFVIFKEVSSATNALRSMQGFPFYDK PMRIQYAKT
DSDIIAKMKGTFVERDRKREKRKPKSQETPATKKAVQGGGATPVVGAVQGPVPGMPPMTQAPRIMHHMPGQ PPYMPPPGMIPPPGLAPG
QIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFLTNLPEETNELMLSMLFNQFPGFKEVRLV PGRHDIAFVEFDNEVQAGAARDALQGF
KITQNNAMKISFAKK
Chain Z,W
MSIGVPIKVLHEAEGHIVTCETNTGEVYRGKLIEAEDNMNCQMSNITVTYRDGRVAQLEQVYIRGSKIRFLILPDMLKNA PMLKSMKNK
NQGSGAGRGKAAILKAQVAARGRGRGMGRGNIFQKRR
Chain S,L
MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQ EVETELKMW
DPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSA YKHADGKKIDGRRVLVDV
ERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRERE RRERSRERDKERERRRSRSRDRRRRSR
SRDKEERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGDMAEPS EAGDAPPDDGPPGELGPDGPDGPEEKGRDRDRERRR
SHRSERERRRDRDRDRDRDREHKRGERGSERGRDEARGGGGGQD NGLEGLGNDSRDMYMESEGGDGYLAPENGYLMEAAPE
Chain X,U
MKLVRFLMKLSHETVTIELKNGTQVHGTITGVDVSMNTHLKAVKMTLKNREPVQLETLSIRGNNIRYFILPDSLPLDTLL VDVEPKVKS
KKREAVAGRGRGRGRGRGRGRGRGRGGPRR
Chain B,Q
MTVGKSSKMLQHIDYRMRCILQDGRIFIGTFKAFDKHMNLILCDCDEFRKIKPKNSKQAEREEKRVLGLVLLRGENLVSM TVEGPPPKD
TGIARVPLAGAAGGPGIGRAAGRGIPAGVPMPQAPAGLAGPVRGVGGPSQQVMTPQGRGTVAAAAAAATAS IAGAPTQYPPGRGGPPPP
MGRGAPPPGMMGPPPGMRPPMGPPMGIPPGRGTPMGMPPPGMRPPPPGMRGLL
Chain F,I
MSLPLNPKPFLNGLTGKPVMVKLKWGMEYKGYLVSVDGYMNMQLANTEEYIDGALSGHLGEVLIRCNNVLYIRGVEEEEE DGEMRE
Chain Y,V
MSLLNKPKSEMTPEELQKREEEEFNTGPLSVLTQSVKNNTQVLINCRNNKKLLGRVKAFDRHCNMVLENVKEMWTEVPKS GKGKKKSKP
VNKDRYISKMFLRGDSVIVVLRNPLIAGK
Chain G,J
MSKAHPPELKKFMDKKLSLKLNGGRHVQGILRGFDPFMNLVIDECVEMATSGQQNNIGMVVIRGNSIIMLEALERV
Chain E,H
MAYRGQGQKVQKVMVQPINLIFRYLQNRSRIQVWLYEQVNMRIEGCIIGFDEYMNLVLDDAEEIHSKTKSRKQLGRIMLK GDNITLLQS
VSN
Primary Citation:
Weber, G., Trowitzsch, S., Kastner, B., Luhrmann, R., Wahl, M.C.
Functional organization of the Sm core in the crystal structure of human U1 snRNP. 
Embo J., 29, pp. 4172 - 4184, 2010.
Experimental Information:
X-RAY DIFFRACTION
Space Group:
C 1 2 1
Cell Constants:
a = 358.42 b = 88.22 c = 150.9 (Ångstroms)
α = 90.0 β = 111.88 γ = 90.0 (degrees)
Refinement:
The structure was refined using the PHENIX program.
The R value is 0.0 for 28077 reflections in
the resolution range 100.0 to 4.4 Ångstroms
with Fobs > 0.0 sigma(Fobs) and with I > 0.0 sigma(I)