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NDB ID: NA0868    PDB ID: 3PIP 


Title:

CRYSTAL STRUCTURE OF THE SYNERGISTIC ANTIBIOTIC PAIR LANKAMYCIN AND LANKACIDIN IN COMPLEX WITH THE LARGE RIBOSOMAL SUBUNIT

Molecular Description:

PROTEIN/RNA Complex

Structural Keywords:

SINGLE STRAND, HAIRPIN LOOP

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 28 protein sequences

Primary Citation:

Belousoff, M.J., Shapira, T., Bashan, A., Zimmerman, E., Rozenberg, H., Arakawa, K., Kinashi, H., Yonath, A.
Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit. 
Proc.Natl.Acad.Sci.USA, 108, pp. 2717 - 2722, 2011.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 2 2 2

Cell Constants:

a = 169.723   b = 408.562   c = 693.334 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX (PHENIX.REFINE: 1.6.4_486) program. The R value is 0.257 for 260194 reflections in the resolution range 19.998 to 3.45 Ångstroms with Fobs >  0.58 sigma(Fobs) and with I >  0.0 sigma(I)