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NDB ID: NA0972    PDB ID: 3QLP 


Title:

X-RAY STRUCTURE OF THE COMPLEX BETWEEN HUMAN ALPHA THROMBIN AND A MODIFIED THROMBIN BINDING APTAMER (MTBA)

Molecular Description:

Thrombin heavy chain (E.C.3.4.21.5)
Thrombin light chain (E.C.3.4.21.5)
DNA

Deposited:

2011-02-03

Released:

2011-10-19

Structural Keywords:

QUADRUPLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Russo Krauss, I., Merlino, A., Giancola, C., Randazzo, A., Mazzarella, L., Sica, F.
Thrombin-aptamer recognition: a revealed ambiguity. 
Nucleic Acids Res., 39, pp. 7858 - 7867, 2011.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 2 2 2

Cell Constants:

a = 68.208   b = 110.574   c = 120.916 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.186 for 23642 reflections in the resolution range 25.1 to 2.14 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)