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NDB ID: NA1022    PDB ID: 3QX3 


Title:

HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND ETOPOSIDE

Molecular Description:

DNA topoisomerase 2-beta (E.C.5.99.1.3)/DNA complex
Etoposide

Deposited:

2011-03-01

Released:

2011-07-06

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Wu, C.C., Li, T.K., Farh, L., Lin, L.Y., Lin, T.S., Yu, Y.J., Yen, T.J., Chiang, C.W., Chan, N.L.
Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide 
Science, 333, pp. 459 - 462, 2011.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 80.149   b = 176.801   c = 94.067 (Ångstroms)

α = 90.0   β = 111.58   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1701 for 117720 reflections in the resolution range 29.543 to 2.162 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)