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NDB ID: NA1087    PDB ID: 3RMA 


Title:

CRYSTAL STRUCTURE OF A REPLICATIVE DNA POLYMERASE BOUND TO DNA CONTAINING THYMINE GLYCOL

Molecular Description:

DNA polymerase (E.C.2.7.7.7)/DNA complex

Deposited:

2011-04-20

Released:

2011-08-10

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASE, FLIPPED-OUT BASE

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Aller, P., Duclos, S., Wallace, S.S., Doublie, S.
A crystallographic study of the role of sequence context in thymine glycol bypass by a replicative DNA polymerase serendipitously sheds light on the exonuclease complex. 
J.Mol.Biol., 412, pp. 22 - 34, 2011.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 132.699   b = 123.0   c = 163.941 (Ångstroms)

α = 90.0   β = 96.08   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 121436 reflections in the resolution range 50.0 to 2.84 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)