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NDB ID: NA1132    PDB ID: 3S4P 


Title:

CRYSTAL STRUCTURE OF THE BACTERIAL RIBOSOMAL DECODING SITE COMPLEXED WITH AN AMPHIPHILIC PAROMOMYCIN O2''-ETHER ANALOGUE

Molecular Description:

5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3'

Structural Keywords:

A DOUBLE HELIX, BULGES, FLIPPED-OUT BASES

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Szychowski, J., Kondo, J., Zahr, O., Auclair, K., Westhof, E., Hanessian, S., Keillor, J.W.
Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues 
Chemmedchem, 6, pp. 1961 - 1966, 2011.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 34.189   b = 44.689   c = 94.585 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 4848 reflections in the resolution range 10.0 to 2.56 Ångstroms with Fobs >  65.0 sigma(Fobs) and with I >  0.0 sigma(I)